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Immunopathology of Chlamydophila abortus infection in sheep and mice.

Kerr K, Entrican G, McKeever D, Longbottom D

International Research Centre, Pentlands Science Park, Moredun Research Institute, Bush Loan, Penicuik, Midlothian, Edinburgh EH26 0PZ, UK.

Chlamydophila abortus targets the placenta, causing tissue damage, inflammation and abortion (enzootic abortion of ewes). It is one of the main infectious causes of abortion in ewes, resulting in major economic losses to agricultural industries worldwide. Although ruminants and pigs are the principal hosts, humans are also susceptible to infection. Control of disease requires a host inflammatory response, which is likely to contribute to pathology and abortion. Mouse models have been widely used to provide insight into the role of specific immune cells in controlling infection and disease. The use of such model systems for investigating the mechanisms of abortion, latency, persistence, and immunity to reinfection will result in the identification of novel vaccine control strategies for sheep.

Published 25 October 2004 in Res Vet Sci, 78(1): 1-7.
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