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Pregnancy outcome in recurrent aborters is not influenced by Chlamydia IgA and/or G.

Sugiura-Ogasawara M, Ozaki Y, Nakanishi T, Kumamoto Y, Suzumori K

Department of Obstetrics and Gynecology, Nagoya City University Medical School, Nagoya, Japan. og.mym@med.nagoya-cu.ac.jp

PROBLEM: It is unclear whether chlamydia infection influences the miscarriage rate and immunological factors in patients with recurrent miscarriage. METHOD OF STUDY: Chlamydia DNA, IgA and IgG to Chlamydia trachomatis, natural killer cell activity, complement 3 (C3), C4, hemolytic complement, antinuclear antibodies, antiphospholipid antibodies, prolactin, activated partial thromboplastin time, prothrombin time and fibrinogen were examined in 504 patients with a history of two or more consecutive first-trimester miscarriages. Subsequent pregnancy outcomes were compared between cases with and without antibodies to C. trachomatis. RESULTS: Totals of 10 of 30 and 48 of 201 patients receiving no medication miscarried subsequently with and without chlamydia infection. Chlamydia IgA and/or IgG were associated with a high level of C3 but not other immunological and coagulatory parameters. CONCLUSION: Antibodies to C. trachomatis do not influence subsequent pregnancy outcome in patients with a history of recurrent miscarriage.

Published 25 January 2005 in Am J Reprod Immunol, 53(1): 50-3.
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