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'Vanishing embryo syndrome' in IVF/ICSI.

Hvidtjørn D, Grove J, Schendel D, Vaeth M, Ernst E, Nielsen L, Thorsen P

NANEA, Department of Epidemiology, Institute of Public Health, University of Aarhus, Denmark. dh@soci.au.dk

BACKGROUND: In a Danish population-based cohort study assessing the risk of cerebral palsy in children born after IVF, we made some interesting observations regarding 'vanishing co-embryos'. METHODS and RESULTS: All live-born children born in Denmark from 1 January 1995 to 31 December 2000 were included in this analysis. The children conceived by IVF/ICSI (9444) were identified through the IVF Register, the children conceived without IVF/ICSI (395 025) were identified through The Danish Medical Birth Register. Main outcome measure was the incidence of cerebral palsy. Within the IVF/ICSI children we found indications of an increased risk of cerebral palsy in those children resulting from pregnancies, where the number of embryos transferred was higher than the number of children born. CONCLUSIONS: The association between vanishing embryo syndrome and incidence of cerebral palsy following IVF requires further investigation in larger, adequately powered, studies.

Published 11 August 2005 in Hum Reprod, 20(9): 2550-1.
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