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Metformin hydrochloride and recurrent miscarriage in a woman with polycystic ovary syndrome.

Palomba S, Falbo A, Orio F, Russo T, Tolino A, Zullo F

Department of Obstetrics and Gynecology, University Magna Graecia of Catanzaro, Italy. stefanopalomba@tin.it

OBJECTIVE: To report the effect of metformin treatment on a patient with recurrent miscarriage (RM) and polycystic ovary syndrome (PCOS). DESIGN: Case report. SETTING: University department of obstetrics and gynecology, Italy. PATIENT(S): A woman complaining of RM who had PCOS and insulin resistance. INTERVENTION(S): Clinical, biochemical, and instrumental assessments. MAIN OUTCOME MEASURE(S): Administration of metformin hydrochloride before and throughout pregnancy. RESULT(S): After 3 months of treatment, the patient became pregnant. The pregnancy had a physiologic development, and at 39 weeks of gestation, the patient spontaneously delivered a healthy infant. CONCLUSION(S): Metformin has shown to be effective in an insulin-resistant PCOS woman with RM.

Published 1 May 2006 in Fertil Steril, 85(5): 1511.e3-5.
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