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Maternal derivative chromosome 9 and recurrent pregnancy loss.

Chang LW, Lee IW, Kuo PL, Kuan LC

Department of Obstetrics and Gynecology, National Cheng Kung University, College of Medicine, Tainan, Taiwan. lckuan@kgh.com.tw

OBJECTIVE: To disclose the relationship between a derivative chromosome 9 and recurrent pregnancy loss. DESIGN: Case report. SETTING: Referral from primary clinical care to tertiary hospital for further intervention. PATIENT(S): A 31-year-old woman who had four recurrent early spontaneous abortions. INTERVENTION(S): Cytogenetic and fluorescence in situ hybridization analyses of the chromosome harvested from peripheral blood sample. MAIN OUTCOME MEASURE(S): Karyotype of the patient. RESULT(S): The patient has a unique derivative chromosome 9, der(9)(9qter-->9p24::9p24-->9p11::9p13-->9qter). ish der(9) (CEP9x1,43N6x1,D9Z3x1). CONCLUSION(S): Maternal derivative chromosome 9 may cause recurrent pregnancy loss.

Published 8 October 2007 in Fertil Steril, 88(4): 968.e1-3.
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